I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 12 studies | 26% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 12 studies | 26% ± 11% |
Insufficient scRNA-seq data for expression of FDXR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 1959.96 | 1809 / 1809 | 99% | 30.92 | 467 / 472 |
| bladder | 100% | 758.57 | 21 / 21 | 99% | 33.46 | 497 / 504 |
| thymus | 99% | 762.85 | 644 / 653 | 99% | 25.22 | 601 / 605 |
| uterus | 98% | 865.85 | 167 / 170 | 100% | 35.49 | 457 / 459 |
| liver | 100% | 750.23 | 225 / 226 | 98% | 23.95 | 398 / 406 |
| prostate | 99% | 866.90 | 242 / 245 | 97% | 13.80 | 488 / 502 |
| brain | 96% | 790.03 | 2536 / 2642 | 100% | 19.79 | 704 / 705 |
| adrenal gland | 100% | 31653.55 | 258 / 258 | 94% | 219.64 | 216 / 230 |
| kidney | 98% | 626.57 | 87 / 89 | 96% | 31.74 | 862 / 901 |
| ovary | 100% | 2670.42 | 180 / 180 | 93% | 14.25 | 398 / 430 |
| intestine | 94% | 587.56 | 910 / 966 | 96% | 22.53 | 507 / 527 |
| pancreas | 95% | 721.95 | 311 / 328 | 95% | 13.83 | 169 / 178 |
| esophagus | 96% | 1169.35 | 1390 / 1445 | 92% | 16.08 | 169 / 183 |
| stomach | 93% | 578.36 | 335 / 359 | 93% | 17.91 | 266 / 286 |
| lung | 89% | 625.99 | 514 / 578 | 94% | 21.13 | 1091 / 1155 |
| breast | 86% | 436.59 | 397 / 459 | 92% | 18.33 | 1027 / 1118 |
| eye | 0% | 0 | 0 / 0 | 100% | 41.64 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 51.12 | 29 / 29 |
| spleen | 100% | 4120.27 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 39.43 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 32.23 | 1 / 1 |
| adipose | 82% | 395.67 | 989 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 80% | 448.29 | 1066 / 1335 | 0% | 0 | 0 / 0 |
| heart | 71% | 328.27 | 614 / 861 | 0% | 0 | 0 / 0 |
| muscle | 57% | 434.89 | 460 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 47% | 847.84 | 439 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0070995 | Biological process | NADPH oxidation |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0006694 | Biological process | steroid biosynthetic process |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0004324 | Molecular function | ferredoxin-NADP+ reductase activity |
| GO_0015039 | Molecular function | NADPH-adrenodoxin reductase activity |
| Gene name | FDXR |
| Protein name | NADPH:adrenodoxin oxidoreductase, mitochondrial (EC 1.18.1.6) NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) Ferredoxin reductase |
| Synonyms | ADXR hCG_29834 |
| Description | FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. . |
| Accessions | ENST00000579482.5 ENST00000582944.5 J3QKZ8 ENST00000420580.6 [P22570-6] ENST00000577509.5 ENST00000579543.1 A0A0A0MTN9 J3KS64 P22570 A0A0A0MSZ4 Q6GSK2 ENST00000582710.5 A0A0A0MT64 ENST00000544854.5 A0A0A0MTR6 A0A0C4DFN8 ENST00000579893.1 ENST00000580492.5 J3QSF9 ENST00000293195.10 ENST00000442102.6 J3KTA3 ENST00000581530.5 A0A0C4DGN7 ENST00000413947.6 ENST00000583917.5 J3KRG8 J3QQW7 ENST00000583881.5 J3QQX3 ENST00000581219.1 |
