ERVW-1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007520Biological processmyoblast fusion
GO_0006949Biological processsyncytium formation
GO_0009653Biological processanatomical structure morphogenesis
GO_0000768Biological processsyncytium formation by plasma membrane fusion
GO_0005886Cellular componentplasma membrane

IV. Literature review

[source]
Gene nameERVW-1
Protein nameSyncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)]
SynonymsERVWE1
DescriptionFUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 . .; FUNCTION: Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

AccessionsQ9UQF0
ENST00000603053.2
ENST00000493463.2