EPX report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EPX at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPX at tissue level.

III. Associated gene sets

GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_0032714Biological processnegative regulation of interleukin-5 production
GO_0042744Biological processhydrogen peroxide catabolic process
GO_0072677Biological processeosinophil migration
GO_0002215Biological processdefense response to nematode
GO_0098869Biological processcellular oxidant detoxification
GO_0006979Biological processresponse to oxidative stress
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0042742Biological processdefense response to bacterium
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0034774Cellular componentsecretory granule lumen
GO_0004601Molecular functionperoxidase activity
GO_0020037Molecular functionheme binding
GO_0140825Molecular functionlactoperoxidase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameEPX
Protein nameEosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]
SynonymsEPP
EPO
EPER
DescriptionFUNCTION: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. .

AccessionsENST00000225371.6
P11678