ENTPD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009134Biological processnucleoside diphosphate catabolic process
GO_0032026Biological processresponse to magnesium ion
GO_0051592Biological processresponse to calcium ion
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0008894Molecular functionguanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO_0004382Molecular functionGDP phosphatase activity
GO_0036384Molecular functionCDP phosphatase activity
GO_0045134Molecular functionUDP phosphatase activity
GO_0017110Molecular functionnucleoside diphosphate phosphatase activity
GO_1990003Molecular functionIDP phosphatase activity
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity

IV. Literature review

[source]
Gene nameENTPD6
Protein nameEctonucleoside triphosphate diphosphohydrolase 6
Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)
SynonymsCD39L2
IL6ST2
DescriptionFUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP . The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides . .

AccessionsENST00000360031.6 [O75354-3]
Q5QPJ7
Q5QPJ6
ENST00000417467.5
ENST00000435520.5
ENST00000447877.5
Q5QPJ3
O75354
H0Y473
Q5QPI9
ENST00000376652.9 [O75354-1]
ENST00000433417.5
ENST00000433259.6
ENST00000376666.3
Q5QPJ4
ENST00000425813.5
H0Y6Q1
H0Y3D0
Q5QPI7
ENST00000354989.9 [O75354-2]
ENST00000439162.5
ENST00000418890.5
H0Y5X0
ENST00000427553.5