ENTPD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046712Biological processGDP catabolic process
GO_0046036Biological processCTP metabolic process
GO_0034656Biological processnucleobase-containing small molecule catabolic process
GO_0006256Biological processUDP catabolic process
GO_0000139Cellular componentGolgi membrane
GO_0000421Cellular componentautophagosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005765Cellular componentlysosomal membrane
GO_0043273Molecular functionCTPase activity
GO_0004382Molecular functionGDP phosphatase activity
GO_0036384Molecular functionCDP phosphatase activity
GO_0045134Molecular functionUDP phosphatase activity
GO_0017110Molecular functionnucleoside diphosphate phosphatase activity
GO_0003924Molecular functionGTPase activity
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity

IV. Literature review

[source]
Gene nameENTPD4
Protein nameEctonucleoside triphosphate diphosphohydrolase 4
Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42)
ENTPD4 protein (Ectonucleoside triphosphate diphosphohydrolase 4)
SynonymsKIAA0392
LYSAL1
LALP70
DescriptionFUNCTION: [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates . Preferentially activated by Ca(2+) over Mg(2+) . .; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. .

AccessionsH0YAN2
ENST00000518471.5
ENST00000417069.6 [Q9Y227-2]
ENST00000358689.9 [Q9Y227-1]
Q9Y227
ENST00000356206.10
ENST00000519839.1
ENST00000518718.1
Q8NE73
H0YBY8
E5RIB2