ELAC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ELAC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ELAC1 at tissue level.

III. Associated gene sets

GO_0042780Biological processtRNA 3'-end processing
GO_0072344Biological processrescue of stalled ribosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004549Molecular functiontRNA-specific ribonuclease activity
GO_0042781Molecular function3'-tRNA processing endoribonuclease activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameELAC1
Protein nameElaC homolog 1 (E. coli), isoform CRA_a (ElaC ribonuclease Z 1)
ElaC ribonuclease Z 1
Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1)
SynonymsD29
hCG_23690
DescriptionFUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity . Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 . tRNAs are then processed by TRNT1 . .

AccessionsENST00000591429.1
ENST00000588577.5
ENST00000269466.8
K7EIJ1
K7EPH7
Q9H777