EFL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046039Biological processGTP metabolic process
GO_0006414Biological processtranslational elongation
GO_0042256Biological processcytosolic ribosome assembly
GO_1990904Cellular componentribonucleoprotein complex
GO_0005829Cellular componentcytosol
GO_0043022Molecular functionribosome binding
GO_0005525Molecular functionGTP binding
GO_0003746Molecular functiontranslation elongation factor activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameEFL1
Protein nameElongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A)
Elongation factor like GTPase 1
SynonymsEFTUD1
FAM42A
DescriptionFUNCTION: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. .

AccessionsH0YKI9
H0YKY7
ENST00000561389.2
ENST00000557939.2
ENST00000650113.1
A0A8Q3SIM9
ENST00000696336.1
ENST00000268206.12 [Q7Z2Z2-1]
H0YNW8
ENST00000557844.1
ENST00000359445.8 [Q7Z2Z2-2]
A0A8Q3SIF5
ENST00000696327.1
ENST00000696330.1 [Q7Z2Z2-1]
A0A3B3ITU1
Q7Z2Z2
A0A8Q3WL51
ENST00000561340.2
ENST00000558974.1
H0YK75