EFCAB9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EFCAB9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EFCAB9 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0030317Biological processflagellated sperm motility
GO_0048240Biological processsperm capacitation
GO_0097228Cellular componentsperm principal piece
GO_0036128Cellular componentCatSper complex
GO_0005737Cellular componentcytoplasm
GO_0061891Molecular functioncalcium ion sensor activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameEFCAB9
Protein nameEF-hand calcium-binding domain-containing protein 9
Synonyms
DescriptionFUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. .

AccessionsENST00000398186.5
A8MZ26