EEFSEC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001514Biological processselenocysteine incorporation
GO_1990904Cellular componentribonucleoprotein complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0000049Molecular functiontRNA binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0035368Molecular functionselenocysteine insertion sequence binding
GO_0003746Molecular functiontranslation elongation factor activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameEEFSEC
Protein nameEukaryotic elongation factor, selenocysteine-tRNA specific (Selenocysteine-specific elongation factor)
Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)
SynonymsSELB
DescriptionFUNCTION: Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons . Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon . Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling . (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation . (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur . .

AccessionsENST00000483457.1
ENST00000644579.2 [P57772-1]
P57772
ENST00000254730.11 [P57772-1]
ENST00000644955.1
C9J8T0