EARS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EARS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EARS2 at tissue level.

III. Associated gene sets

GO_0006424Biological processglutamyl-tRNA aminoacylation
GO_0070127Biological processtRNA aminoacylation for mitochondrial protein translation
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0000049Molecular functiontRNA binding
GO_0050561Molecular functionglutamate-tRNA(Gln) ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004818Molecular functionglutamate-tRNA ligase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameEARS2
Protein nameGlutamyl-tRNA synthetase 2, mitochondrial
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.17) (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (Glutamyl-tRNA synthetase) (Mitochondrial glutamyl-tRNA synthetase)
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS)
SynonymsKIAA1970
DescriptionFUNCTION: Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation . Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln) . In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity . .

AccessionsH3BQP8
ENST00000563232.1 [Q5JPH6-2]
ENST00000449606.7 [Q5JPH6-1]
ENST00000674054.1 [Q5JPH6-1]
ENST00000564668.5
H3BTB7
ENST00000562581.5
H3BQI0
Q5JPH6
H3BPY3
ENST00000564997.1
I3L166
ENST00000563499.1
ENST00000564501.5