I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 22% ± 6% | |
| pericyte | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 22% ± 6% | |
| pericyte | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of DUSP8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 6576.81 | 2612 / 2642 | 98% | 21.02 | 689 / 705 |
| intestine | 93% | 2239.28 | 903 / 966 | 98% | 21.35 | 516 / 527 |
| pancreas | 94% | 1937.56 | 307 / 328 | 91% | 12.46 | 162 / 178 |
| lung | 94% | 2166.31 | 546 / 578 | 83% | 9.26 | 962 / 1155 |
| breast | 81% | 1398.83 | 372 / 459 | 94% | 13.39 | 1052 / 1118 |
| stomach | 71% | 1392.98 | 256 / 359 | 97% | 21.23 | 276 / 286 |
| uterus | 89% | 1946.78 | 151 / 170 | 75% | 7.08 | 342 / 459 |
| prostate | 64% | 1071.02 | 156 / 245 | 94% | 9.79 | 470 / 502 |
| kidney | 75% | 990.99 | 67 / 89 | 82% | 8.52 | 738 / 901 |
| esophagus | 59% | 1227.37 | 854 / 1445 | 95% | 15.90 | 173 / 183 |
| thymus | 57% | 742.36 | 374 / 653 | 83% | 8.58 | 501 / 605 |
| bladder | 52% | 677.19 | 11 / 21 | 59% | 8.07 | 298 / 504 |
| ovary | 21% | 343.66 | 37 / 180 | 86% | 10.79 | 368 / 430 |
| adrenal gland | 19% | 246.47 | 50 / 258 | 82% | 25.19 | 188 / 230 |
| eye | 0% | 0 | 0 / 0 | 100% | 24.80 | 80 / 80 |
| liver | 23% | 313.03 | 52 / 226 | 76% | 7.54 | 308 / 406 |
| blood vessel | 98% | 3458.93 | 1304 / 1335 | 0% | 0 | 0 / 0 |
| heart | 95% | 2212.62 | 818 / 861 | 0% | 0 | 0 / 0 |
| skin | 46% | 548.81 | 834 / 1809 | 47% | 4.39 | 223 / 472 |
| muscle | 92% | 1609.99 | 738 / 803 | 0% | 0 | 0 / 0 |
| adipose | 79% | 1161.68 | 956 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 4.86 | 30 / 45 |
| spleen | 46% | 479.59 | 112 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 14% | 157.35 | 129 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.40 | 3 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043409 | Biological process | negative regulation of MAPK cascade |
| GO_0035335 | Biological process | peptidyl-tyrosine dephosphorylation |
| GO_0016311 | Biological process | dephosphorylation |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0017017 | Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| GO_0016791 | Molecular function | phosphatase activity |
| GO_0017018 | Molecular function | myosin phosphatase activity |
| GO_0008330 | Molecular function | protein tyrosine/threonine phosphatase activity |
| GO_0033550 | Molecular function | MAP kinase tyrosine phosphatase activity |
| Gene name | DUSP8 |
| Protein name | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) |
| Synonyms | C11orf81 VH5 |
| Description | FUNCTION: Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues. . |
| Accessions | ENST00000707550.1 ENST00000610856.1 ENST00000397374.8 ENST00000625578.2 ENST00000331588.4 ENST00000707551.1 ENST00000617829.1 ENST00000629053.2 Q13202 |
