DTX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0016567Biological processprotein ubiquitination
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0007219Biological processNotch signaling pathway
GO_0032479Biological processregulation of type I interferon production
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0010498Biological processproteasomal protein catabolic process
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameDTX4
Protein nameE3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)
SynonymsKIAA0937
RNF155
DescriptionFUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. .

AccessionsENST00000227451.4 [Q9Y2E6-1]
ENST00000532982.5 [Q9Y2E6-2]
Q9Y2E6