DPY19L3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006486Biological processprotein glycosylation
GO_0018406Biological processprotein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
GO_0005637Cellular componentnuclear inner membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000030Molecular functionmannosyltransferase activity

IV. Literature review

[source]
Gene nameDPY19L3
Protein nameDpy-19 like C-mannosyltransferase 3 (Dpy-19-like 3 (C. elegans))
Protein C-mannosyl-transferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3)
Dpy-19 like C-mannosyltransferase 3
Synonyms
DescriptionFUNCTION: C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence . C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW . C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (By similarity). .; FUNCTION: [Isoform 2]: Has no C-mannosyltransferase activity. .

AccessionsENST00000342179.9 [Q6ZPD9-1]
K7ELG1
ENST00000392250.7 [Q6ZPD9-1]
Q6ZPD9
ENST00000588648.7
S4R3D3
K7ELB5
ENST00000586427.1
Q8N6Q4
ENST00000586987.5
K7ELH8
ENST00000587077.6
ENST00000592832.2