DPEP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DPEP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DPEP3 at tissue level.

III. Associated gene sets

GO_0006508Biological processproteolysis
GO_0098552Cellular componentside of membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0016805Molecular functiondipeptidase activity

IV. Literature review

[source]
Gene nameDPEP3
Protein nameDipeptidase 3
Dipeptidase 3, isoform CRA_c (Testis secretory sperm-binding protein Li 211a)
SynonymsUNQ834/PRO1772
hCG_1819769
DescriptionFUNCTION: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem . The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide . A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance . .

AccessionsENST00000672962.1
ENST00000268793.6
A0A5F9ZHB4
A0A140VK16
Q9H4B8