I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| non-classical monocyte | 10 studies | 27% ± 10% | |
| classical monocyte | 7 studies | 22% ± 3% | |
| macrophage | 7 studies | 17% ± 2% | |
| monocyte | 4 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| non-classical monocyte | 10 studies | 27% ± 10% | |
| classical monocyte | 7 studies | 22% ± 3% | |
| macrophage | 7 studies | 17% ± 2% | |
| monocyte | 4 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of DPEP2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1001.67 | 577 / 578 | 81% | 2.94 | 932 / 1155 |
| thymus | 91% | 232.77 | 593 / 653 | 80% | 2.23 | 486 / 605 |
| kidney | 72% | 124.64 | 64 / 89 | 86% | 4.02 | 773 / 901 |
| breast | 85% | 170.11 | 389 / 459 | 71% | 1.76 | 798 / 1118 |
| bladder | 81% | 201.52 | 17 / 21 | 68% | 3.10 | 342 / 504 |
| intestine | 93% | 407.86 | 900 / 966 | 48% | 1.20 | 252 / 527 |
| brain | 44% | 53.11 | 1153 / 2642 | 95% | 2.85 | 668 / 705 |
| prostate | 76% | 128.54 | 185 / 245 | 51% | 0.94 | 256 / 502 |
| stomach | 66% | 88.78 | 236 / 359 | 59% | 1.48 | 170 / 286 |
| uterus | 74% | 103.12 | 126 / 170 | 49% | 1.25 | 225 / 459 |
| esophagus | 74% | 123.11 | 1073 / 1445 | 40% | 0.96 | 73 / 183 |
| skin | 44% | 53.88 | 792 / 1809 | 59% | 1.80 | 279 / 472 |
| liver | 65% | 82.13 | 147 / 226 | 37% | 0.78 | 150 / 406 |
| pancreas | 14% | 23.40 | 46 / 328 | 87% | 4.00 | 155 / 178 |
| spleen | 100% | 2413.37 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 4558.61 | 912 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 7.98 | 28 / 29 |
| adipose | 95% | 314.81 | 1144 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 44% | 51.42 | 113 / 258 | 31% | 0.57 | 72 / 230 |
| heart | 68% | 95.61 | 584 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 1.77 | 29 / 45 |
| ovary | 22% | 31.24 | 39 / 180 | 42% | 0.78 | 182 / 430 |
| blood vessel | 55% | 119.13 | 734 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 37% | 35.02 | 297 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 28% | 0.52 | 22 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006691 | Biological process | leukotriene metabolic process |
| GO_0006508 | Biological process | proteolysis |
| GO_1901749 | Biological process | leukotriene D4 catabolic process |
| GO_0098552 | Cellular component | side of membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0070573 | Molecular function | metallodipeptidase activity |
| GO_0016805 | Molecular function | dipeptidase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | DPEP2 |
| Protein name | Dipeptidase (EC 3.4.13.19) Dipeptidase 2 Dipeptidase 2 (EC 3.4.13.19) |
| Synonyms | UNQ284/PRO323 |
| Description | FUNCTION: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) . Hydrolyzes cystinyl-bis-glycine . .; FUNCTION: Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway. . |
| Accessions | J3QLL2 ENST00000393847.6 [Q9H4A9-1] ENST00000575203.5 [Q9H4A9-3] ENST00000574865.1 ENST00000572888.5 [Q9H4A9-1] J3KSU4 ENST00000575510.5 I3L348 Q9H4A9 ENST00000572624.5 ENST00000573808.1 I3L4H3 |
