DMP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DMP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DMP1 at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0001503Biological processossification
GO_0031214Biological processbiomineral tissue development
GO_0070173Biological processregulation of enamel mineralization
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0005634Cellular componentnucleus
GO_0050840Molecular functionextracellular matrix binding
GO_0005509Molecular functioncalcium ion binding
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameDMP1
Protein nameDentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1)
Dentin matrix acidic phosphoprotein 1
Synonyms
DescriptionFUNCTION: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. .

AccessionsA0A804HJB8
ENST00000682752.1
ENST00000339673.11 [Q13316-1]
Q13316
ENST00000282479.8 [Q13316-2]