Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 8 studies | 32% ± 12% | |
| fibroblast | 6 studies | 29% ± 14% | |
| extravillous trophoblast | 3 studies | 73% ± 5% | |
| epithelial cell | 3 studies | 22% ± 4% | |
| Mueller cell | 3 studies | 48% ± 15% |
Insufficient scRNA-seq data for expression of DIO2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 17033.69 | 653 / 653 | 85% | 102.69 | 516 / 605 |
| prostate | 92% | 2687.69 | 225 / 245 | 92% | 16.46 | 460 / 502 |
| esophagus | 84% | 6162.83 | 1219 / 1445 | 88% | 21.56 | 161 / 183 |
| brain | 72% | 2567.56 | 1910 / 2642 | 74% | 15.96 | 525 / 705 |
| stomach | 34% | 354.83 | 123 / 359 | 73% | 12.80 | 209 / 286 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.59 | 1 / 1 |
| breast | 20% | 344.54 | 90 / 459 | 79% | 17.39 | 881 / 1118 |
| uterus | 24% | 969.78 | 41 / 170 | 67% | 15.89 | 306 / 459 |
| skin | 60% | 990.05 | 1092 / 1809 | 26% | 3.52 | 123 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 17.58 | 35 / 45 |
| pancreas | 2% | 17.77 | 6 / 328 | 75% | 10.92 | 133 / 178 |
| lung | 6% | 57.31 | 34 / 578 | 60% | 10.34 | 696 / 1155 |
| bladder | 24% | 247.00 | 5 / 21 | 41% | 6.09 | 207 / 504 |
| intestine | 4% | 35.81 | 39 / 966 | 53% | 6.69 | 277 / 527 |
| muscle | 44% | 861.74 | 357 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 44% | 536.38 | 591 / 1335 | 0% | 0 | 0 / 0 |
| heart | 34% | 564.69 | 291 / 861 | 0% | 0 | 0 / 0 |
| kidney | 11% | 118.31 | 10 / 89 | 14% | 1.74 | 130 / 901 |
| ovary | 1% | 30.88 | 2 / 180 | 16% | 1.42 | 68 / 430 |
| adrenal gland | 13% | 400.22 | 34 / 258 | 3% | 0.33 | 7 / 230 |
| adipose | 12% | 136.34 | 150 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 11% | 1.04 | 9 / 80 |
| liver | 0% | 0 | 0 / 226 | 8% | 1.12 | 32 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0042446 | Biological process | hormone biosynthetic process |
| GO_0006590 | Biological process | thyroid hormone generation |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0001514 | Biological process | selenocysteine incorporation |
| GO_0042403 | Biological process | thyroid hormone metabolic process |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0033798 | Molecular function | thyroxine 5-deiodinase activity |
| GO_0008430 | Molecular function | selenium binding |
| GO_0004800 | Molecular function | thyroxine 5'-deiodinase activity |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| Gene name | DIO2 |
| Protein name | Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) Iodothyronine deiodinase 2 Iodothyronine deiodinase |
| Synonyms | hCG_20551 ITDI2 TXDI2 |
| Description | FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). . FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). . FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). . |
| Accessions | ENST00000554188.5 G3V3A8 Q92813 Q9C0K2 Q9NZL0 G3V2A7 ENST00000557125.1 ENST00000557010.5 [Q92813-1] H0YJ42 ENST00000555750.2 ENST00000556811.5 H0YJQ8 A0A024R6J8 ENST00000438257.9 [Q92813-1] ENST00000555844.1 |
