DIO1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DIO1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DIO1 at tissue level.

III. Associated gene sets

GO_0042446Biological processhormone biosynthetic process
GO_0006590Biological processthyroid hormone generation
GO_0042403Biological processthyroid hormone metabolic process
GO_0006520Biological processamino acid metabolic process
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008430Molecular functionselenium binding
GO_0004800Molecular functionthyroxine 5'-deiodinase activity

IV. Literature review

[source]
Gene nameDIO1
Protein nameIodothyronine deiodinase 1
Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)
Iodothyronine deiodinase
SynonymshCG_1790306
TXDI1
ITDI1
DescriptionFUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. .

FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). .

FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). .

FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). .

FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). .

AccessionsP49895
E9PI35
ENST00000388876.3 [P49895-4]
ENST00000528946.5
ENST00000529589.5
ENST00000525044.5
ENST00000322679.10 [P49895-5]
ENST00000530084.5
ENST00000524406.5
C6ZRC2
A8K415
ENST00000527060.5
A0A182DWI2
ENST00000532493.5 [P49895-7]
ENST00000361921.8 [P49895-1]
ENST00000529329.1
ENST00000525202.5 [P49895-2]
F6RP93
E9PM07