DHRS7C report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DHRS7C at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHRS7C at tissue level.

III. Associated gene sets

GO_0010880Biological processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0046323Biological processglucose import
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0014801Cellular componentlongitudinal sarcoplasmic reticulum
GO_0004745Molecular functionall-trans-retinol dehydrogenase (NAD+) activity
GO_0016616Molecular functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

IV. Literature review

[source]
Gene nameDHRS7C
Protein nameDehydrogenase/reductase SDR family member 7C (EC 1.1.1.105) (Sarcoplasmic reticulum protein of 35 kDa) (Protein SRP-35) (Short-chain dehydrogenase/reductase family 32C member 2) (Protein SDR32C2)
Dehydrogenase/reductase SDR family member 7C (Short-chain dehydrogenase/reductase family 32C member 2)
SynonymsSDR32C2
DescriptionFUNCTION: NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid. .

AccessionsENST00000571771.5
ENST00000330255.9 [A6NNS2-1]
ENST00000571134.2 [A6NNS2-2]
A6NNS2
I3NI52