DHRS11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0006694Biological processsteroid biosynthetic process
GO_0005575Cellular componentcellular_component
GO_0005576Cellular componentextracellular region
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0072555Molecular function17-beta-ketosteroid reductase (NADPH) activity
GO_0072582Molecular function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO_0000166Molecular functionnucleotide binding
GO_0000253Molecular function3-keto sterol reductase activity

IV. Literature review

[source]
Gene nameDHRS11
Protein nameDehydrogenase/reductase 11 (Dehydrogenase/reductase SDR family member 11)
Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)
SynonymsUNQ836/PRO1774
SDR24C1
DescriptionFUNCTION: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. .

AccessionsENST00000631686.1 [Q6UWP2-2]
ENST00000632185.1
ENST00000631945.1
A0A087X0R1
ENST00000618403.5 [Q6UWP2-1]
ENST00000612538.1
ENST00000615432.4
ENST00000621871.1
ENST00000621143.2 [Q6UWP2-1]
A0A087WZN3
Q6UWP2
A0A087WYV4
ENST00000633383.1
ENST00000611337.4 [Q6UWP2-2]