DHFR2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DHFR2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHFR2 at tissue level.

III. Associated gene sets

GO_0046105Biological processthymidine biosynthetic process
GO_0046655Biological processfolic acid metabolic process
GO_0006730Biological processone-carbon metabolic process
GO_0046653Biological processtetrahydrofolate metabolic process
GO_0046654Biological processtetrahydrofolate biosynthetic process
GO_0046452Biological processdihydrofolate metabolic process
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0033560Molecular functionfolate reductase activity
GO_0050661Molecular functionNADP binding
GO_0004146Molecular functiondihydrofolate reductase activity
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameDHFR2
Protein namedihydrofolate reductase (EC 1.5.1.3)
Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)
SynonymsDHFRP4
DHFRL1
DescriptionFUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. .

AccessionsENST00000619045.1
ENST00000461173.5
ENST00000314636.3
Q86XF0
C9JJ68
ENST00000496983.1
ENST00000394221.3