DEFB126 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DEFB126 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFB126 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0007338Biological processsingle fertilization
GO_0005576Cellular componentextracellular region

IV. Literature review

[source]
Gene nameDEFB126
Protein nameBeta-defensin 126 (Beta-defensin 26) (DEFB-26) (Defensin, beta 126) (Epididymal secretory protein 13.2) (ESP13.2) (HBD26)
SynonymsC20orf8
DEFB26
DescriptionFUNCTION: Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation . .

AccessionsENST00000382398.4
Q9BYW3