DEFA3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFA3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	90%	4654.91	217 / 241	0%	0	0 / 0
lung	81%	1384.78	470 / 578	4%	0.14	51 / 1155
peripheral blood	79%	22394.33	733 / 929	0%	0	0 / 0
liver	40%	111.00	90 / 226	2%	0.15	8 / 406
thymus	23%	30.77	148 / 653	8%	0.51	48 / 605
heart	27%	62.37	234 / 861	0%	0	0 / 0
kidney	19%	17.62	17 / 89	8%	0.39	70 / 901
adipose	26%	50.52	311 / 1204	0%	0	0 / 0
brain	13%	16.06	353 / 2642	10%	0.61	68 / 705
breast	20%	32.26	93 / 459	1%	0.04	14 / 1118
muscle	13%	16.83	108 / 803	0%	0	0 / 0
adrenal gland	5%	3.91	12 / 258	8%	1.53	19 / 230
uterus	9%	11.16	16 / 170	3%	0.05	12 / 459
blood vessel	10%	17.41	132 / 1335	0%	0	0 / 0
ovary	7%	5.93	13 / 180	1%	0.01	4 / 430
stomach	4%	7.00	14 / 359	4%	0.07	12 / 286
esophagus	5%	7.87	71 / 1445	2%	0.04	4 / 183
lymph node	0%	0	0 / 0	7%	0.25	2 / 29
bladder	5%	2.86	1 / 21	2%	0.04	8 / 504
intestine	3%	4.35	32 / 966	2%	0.03	10 / 527
pancreas	2%	3.02	5 / 328	3%	0.08	6 / 178
skin	2%	2.08	44 / 1809	1%	0.04	4 / 472
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
prostate	2%	0.91	4 / 245	0%	0.01	2 / 502
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0051607	Biological process	defense response to virus
GO_0051673	Biological process	disruption of plasma membrane integrity in another organism
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0031640	Biological process	killing of cells of another organism
GO_0002227	Biological process	innate immune response in mucosa
GO_0050832	Biological process	defense response to fungus
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0030520	Biological process	estrogen receptor signaling pathway
GO_0019731	Biological process	antibacterial humoral response
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0042803	Molecular function	protein homodimerization activity
GO_0003674	Molecular function	molecular_function

Gene name	DEFA3
Protein name	Defensin, alpha 3, neutrophil-specific Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]
Synonyms	DEF3
Description	FUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses . Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus . Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment . .
Accessions	Q6EZE9 P59666 ENST00000327857.7

DEFA3 report