Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 7 studies | 20% ± 4% | |
| B cell | 6 studies | 20% ± 2% | |
| classical monocyte | 6 studies | 22% ± 6% | |
| retinal ganglion cell | 3 studies | 50% ± 26% | |
| epithelial cell | 3 studies | 25% ± 1% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| germinal center B cell | 3 studies | 29% ± 12% | |
| plasmablast | 3 studies | 31% ± 15% | |
| macrophage | 3 studies | 19% ± 1% | |
| astrocyte | 3 studies | 20% ± 3% | |
| dendritic cell | 3 studies | 30% ± 9% | |
| pancreatic A cell | 3 studies | 21% ± 2% | |
| plasmacytoid dendritic cell | 3 studies | 23% ± 7% |
Insufficient scRNA-seq data for expression of DEF8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 7178.69 | 2642 / 2642 | 100% | 47.12 | 705 / 705 |
| skin | 100% | 4276.07 | 1809 / 1809 | 100% | 38.70 | 472 / 472 |
| thymus | 100% | 5277.54 | 653 / 653 | 100% | 38.83 | 605 / 605 |
| prostate | 100% | 4917.07 | 245 / 245 | 100% | 23.67 | 501 / 502 |
| kidney | 100% | 4639.70 | 89 / 89 | 100% | 27.86 | 898 / 901 |
| lung | 100% | 4611.71 | 578 / 578 | 100% | 23.79 | 1150 / 1155 |
| adrenal gland | 100% | 3961.40 | 258 / 258 | 100% | 34.78 | 229 / 230 |
| esophagus | 100% | 4283.15 | 1445 / 1445 | 99% | 18.58 | 182 / 183 |
| pancreas | 100% | 3256.92 | 328 / 328 | 99% | 25.68 | 177 / 178 |
| bladder | 100% | 4355.00 | 21 / 21 | 99% | 25.54 | 501 / 504 |
| uterus | 100% | 5166.99 | 170 / 170 | 99% | 25.49 | 456 / 459 |
| stomach | 100% | 3546.99 | 359 / 359 | 99% | 20.99 | 284 / 286 |
| intestine | 100% | 4074.61 | 966 / 966 | 99% | 23.56 | 522 / 527 |
| breast | 100% | 3752.53 | 459 / 459 | 99% | 20.26 | 1105 / 1118 |
| ovary | 100% | 5622.26 | 180 / 180 | 97% | 15.36 | 419 / 430 |
| liver | 100% | 2043.71 | 226 / 226 | 97% | 14.14 | 395 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 33.67 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 46.54 | 29 / 29 |
| spleen | 100% | 6074.57 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.45 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.49 | 1 / 1 |
| adipose | 100% | 3643.21 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3391.07 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 2737.26 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 7021.97 | 908 / 929 | 0% | 0 | 0 / 0 |
| muscle | 97% | 1877.91 | 782 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1900029 | Biological process | positive regulation of ruffle assembly |
| GO_0045780 | Biological process | positive regulation of bone resorption |
| GO_0032418 | Biological process | lysosome localization |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | DEF8 |
| Protein name | Differentially expressed in FDCP 8 homolog (DEF-8) Alternative protein DEF8 Differentially expressed in FDCP 8 homolog |
| Synonyms | |
| Description | FUNCTION: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. . |
| Accessions | ENST00000563594.6 [Q6ZN54-5] H3BRA7 ENST00000567874.5 [Q6ZN54-4] L8EAV7 ENST00000567999.5 ENST00000564836.1 ENST00000569061.5 ENST00000562986.5 H3BT01 ENST00000562578.5 H3BQ81 ENST00000561959.5 H3BSH6 H3BMT5 H3BTS7 ENST00000563795.1 [Q6ZN54-6] ENST00000610455.4 [Q6ZN54-2] H3BMP4 ENST00000268676.11 [Q6ZN54-1] ENST00000566079.5 H3BQX9 H3BNN0 Q6ZN54 H3BQH5 ENST00000569453.5 [Q6ZN54-5] ENST00000418391.6 [Q6ZN54-2] ENST00000617948.4 [Q6ZN54-5] ENST00000561784.5 ENST00000561741.5 ENST00000567884.5 H3BT87 ENST00000566820.5 ENST00000570182.5 [Q6ZN54-3] |