DCLRE1A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCLRE1A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCLRE1A at tissue level.

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0051301Biological processcell division
GO_0036297Biological processinterstrand cross-link repair
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0035312Molecular function5'-3' DNA exonuclease activity
GO_0003684Molecular functiondamaged DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0008800Molecular functionbeta-lactamase activity

IV. Literature review

[source]
Gene nameDCLRE1A
Protein nameDNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)
SynonymsKIAA0086
SNM1
SNM1A
DescriptionFUNCTION: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin . Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) . .

AccessionsENST00000361384.7
Q6PJP8
ENST00000369305.1