DAND5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DAND5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DAND5 at tissue level.

III. Associated gene sets

GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0035582Biological processsequestering of BMP in extracellular matrix
GO_0003283Biological processatrial septum development
GO_0003140Biological processdetermination of left/right asymmetry in lateral mesoderm
GO_1900108Biological processnegative regulation of nodal signaling pathway
GO_0038101Biological processsequestering of nodal from receptor via nodal binding
GO_0003281Biological processventricular septum development
GO_0061371Biological processdetermination of heart left/right asymmetry
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0007368Biological processdetermination of left/right symmetry
GO_0038092Biological processnodal signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016015Molecular functionmorphogen activity

IV. Literature review

[source]
Gene nameDAND5
Protein nameDAN domain family member 5 (Cerberus-like protein 2) (Cerl-2) (Cysteine knot superfamily 1, BMP antagonist 3) (Gremlin-3)
DAN domain BMP antagonist family member 5 (DAN domain family, member 5, isoform CRA_b)
SynonymshCG_2000988
GREM3
CKTSF1B3
SP1
CER2
DescriptionFUNCTION: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). .

AccessionsENST00000585548.1
ENST00000317060.4
K7EQF6
Q8N907