DACT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DACT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DACT2 at tissue level.

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0003382Biological processepithelial cell morphogenesis
GO_0007162Biological processnegative regulation of cell adhesion
GO_1900108Biological processnegative regulation of nodal signaling pathway
GO_0043588Biological processskin development
GO_0072061Biological processinner medullary collecting duct development
GO_0005737Cellular componentcytoplasm
GO_0008134Molecular functiontranscription factor binding
GO_0005080Molecular functionprotein kinase C binding
GO_0070097Molecular functiondelta-catenin binding
GO_0051018Molecular functionprotein kinase A binding
GO_0008013Molecular functionbeta-catenin binding

IV. Literature review

[source]
Gene nameDACT2
Protein nameDapper homolog 2 (Dapper antagonist of catenin 2)
SynonymsC6orf116
PP13671
DescriptionFUNCTION: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). .

AccessionsENST00000607983.1 [Q5SW24-3]
Q5SW24
ENST00000366796.7 [Q5SW24-4]
ENST00000366795.4 [Q5SW24-1]
ENST00000610183.1 [Q5SW24-2]