D2HGDH | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	5 studies	30% ± 10%	Explore
endothelial cell	4 studies	22% ± 7%	Explore
basal cell	4 studies	30% ± 11%	Explore
macrophage	4 studies	20% ± 3%	Explore
goblet cell	4 studies	30% ± 8%	Explore
ciliated cell	3 studies	22% ± 6%	Explore
hepatocyte	3 studies	27% ± 10%	Explore
astrocyte	3 studies	28% ± 3%	Explore
microglial cell	3 studies	17% ± 1%	Explore
oligodendrocyte precursor cell	3 studies	25% ± 5%	Explore
fibroblast	3 studies	21% ± 4%	Explore
transit amplifying cell	3 studies	29% ± 14%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	23% ± 4%	Explore
intestine	3 studies	16% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	6378.69	245 / 245	99%	26.56	499 / 502
thymus	100%	6975.92	653 / 653	99%	19.24	601 / 605
liver	100%	3197.26	226 / 226	99%	15.88	403 / 406
esophagus	100%	2778.62	1439 / 1445	99%	13.54	182 / 183
intestine	100%	3560.53	966 / 966	99%	18.02	520 / 527
adrenal gland	100%	3420.43	258 / 258	98%	11.83	225 / 230
uterus	100%	4764.36	170 / 170	98%	16.58	449 / 459
bladder	100%	3695.00	21 / 21	98%	17.36	493 / 504
pancreas	100%	2472.16	328 / 328	98%	18.16	174 / 178
kidney	100%	4429.21	89 / 89	97%	17.64	878 / 901
stomach	100%	2700.91	359 / 359	97%	14.67	276 / 286
ovary	100%	4275.17	180 / 180	94%	14.16	405 / 430
breast	100%	3408.31	459 / 459	94%	13.50	1046 / 1118
lung	100%	2996.25	576 / 578	93%	13.90	1076 / 1155
skin	100%	4182.60	1809 / 1809	93%	10.81	437 / 472
brain	93%	1251.91	2444 / 2642	99%	17.26	695 / 705
lymph node	0%	0	0 / 0	100%	18.86	29 / 29
spleen	100%	4214.03	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	32.09	1 / 1
adipose	100%	2725.43	1203 / 1204	0%	0	0 / 0
muscle	99%	1955.78	794 / 803	0%	0	0 / 0
blood vessel	99%	2103.98	1319 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	16.29	79 / 80
tonsil	0%	0	0 / 0	96%	13.26	43 / 45
heart	94%	1415.41	807 / 861	0%	0	0 / 0
peripheral blood	82%	1514.11	765 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0019538	Biological process	protein metabolic process
GO_0006103	Biological process	2-oxoglutarate metabolic process
GO_0006108	Biological process	malate metabolic process
GO_0010043	Biological process	response to zinc ion
GO_0010042	Biological process	response to manganese ion
GO_0032025	Biological process	response to cobalt ion
GO_0032026	Biological process	response to magnesium ion
GO_0051592	Biological process	response to calcium ion
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0071949	Molecular function	FAD binding
GO_0051990	Molecular function	(R)-2-hydroxyglutarate dehydrogenase activity
GO_0008270	Molecular function	zinc ion binding

Gene name	D2HGDH
Protein name	D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) D-2-hydroxyglutarate dehydrogenase
Synonyms	D2HGD hCG_31745
Description	FUNCTION: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate . Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) . Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC . .
Accessions	ENST00000403782.5 ENST00000432449.1 Q8N465 ENST00000437164.1 ENST00000454048.1 ENST00000417686.1 H7C3L2 ENST00000321264.9 [Q8N465-1] H7C021 ENST00000436747.5 ENST00000400769.6 G5E9E8 H7C290 H7C0N1 F8WCF9 B5MCV2

D2HGDH report