CYP7A1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP7A1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	91%	1521.73	206 / 226	77%	75.53	311 / 406
breast	98%	20.60	448 / 459	0%	0.01	3 / 1118
spleen	98%	25.47	235 / 241	0%	0	0 / 0
adipose	97%	30.20	1171 / 1204	0%	0	0 / 0
uterus	87%	9.68	148 / 170	0%	0.01	1 / 459
skin	72%	10.25	1300 / 1809	10%	0.30	49 / 472
bladder	76%	6.10	16 / 21	0%	0	0 / 504
blood vessel	75%	8.07	1005 / 1335	0%	0	0 / 0
lung	73%	7.51	422 / 578	0%	0.02	5 / 1155
ovary	73%	6.33	131 / 180	0%	0.01	1 / 430
thymus	72%	6.61	473 / 653	0%	0	0 / 605
intestine	68%	5.83	660 / 966	2%	0.05	8 / 527
prostate	64%	4.98	158 / 245	0%	0.01	2 / 502
esophagus	63%	5.84	906 / 1445	2%	0.04	4 / 183
adrenal gland	54%	3.86	139 / 258	0%	0	0 / 230
stomach	45%	3.51	162 / 359	2%	0.14	6 / 286
heart	47%	3.10	403 / 861	0%	0	0 / 0
kidney	46%	3.53	41 / 89	0%	0.09	3 / 901
brain	43%	2.84	1147 / 2642	0%	0.00	1 / 705
muscle	37%	2.44	301 / 803	0%	0	0 / 0
peripheral blood	30%	2.64	279 / 929	0%	0	0 / 0
pancreas	24%	1.43	79 / 328	0%	0	0 / 178
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0071333	Biological process	cellular response to glucose stimulus
GO_0032966	Biological process	negative regulation of collagen biosynthetic process
GO_0016125	Biological process	sterol metabolic process
GO_0045471	Biological process	response to ethanol
GO_0015721	Biological process	bile acid and bile salt transport
GO_0038183	Biological process	bile acid signaling pathway
GO_0071397	Biological process	cellular response to cholesterol
GO_0045717	Biological process	negative regulation of fatty acid biosynthetic process
GO_0070857	Biological process	regulation of bile acid biosynthetic process
GO_0006699	Biological process	bile acid biosynthetic process
GO_0045542	Biological process	positive regulation of cholesterol biosynthetic process
GO_0042632	Biological process	cholesterol homeostasis
GO_0006707	Biological process	cholesterol catabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0008123	Molecular function	cholesterol 7-alpha-monooxygenase activity
GO_0033782	Molecular function	24-hydroxycholesterol 7alpha-hydroxylase activity
GO_0005506	Molecular function	iron ion binding
GO_0020037	Molecular function	heme binding

Gene name	CYP7A1
Protein name	Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)
Synonyms	CYP7
Description	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis . 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol . Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives . .
Accessions	ENST00000301645.4 P22680

CYP7A1 report