CYP51A1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	5 studies	26% ± 5%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 15%	Explore
oligodendrocyte	5 studies	18% ± 1%	Explore
epithelial cell	3 studies	22% ± 5%	Explore
retinal ganglion cell	3 studies	37% ± 15%	Explore
GABAergic neuron	3 studies	34% ± 15%	Explore
interneuron	3 studies	36% ± 16%	Explore

Name	Number of supported studies	Average coverage
brain	5 studies	30% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	95%	113.23	341 / 359	92%	5.24	262 / 286
intestine	89%	118.14	863 / 966	94%	5.76	496 / 527
skin	99%	188.96	1785 / 1809	81%	3.03	380 / 472
brain	87%	104.27	2308 / 2642	92%	4.00	647 / 705
pancreas	92%	91.50	301 / 328	85%	2.71	151 / 178
lung	92%	159.22	532 / 578	84%	2.92	975 / 1155
esophagus	84%	129.49	1207 / 1445	91%	4.44	167 / 183
breast	96%	76.94	440 / 459	75%	2.13	842 / 1118
bladder	95%	81.00	20 / 21	68%	2.91	343 / 504
adrenal gland	91%	288.21	235 / 258	67%	3.49	154 / 230
thymus	90%	75.67	585 / 653	62%	1.38	377 / 605
ovary	98%	160.34	177 / 180	51%	0.90	219 / 430
prostate	71%	47.08	173 / 245	77%	2.44	388 / 502
liver	73%	121.46	164 / 226	72%	3.59	291 / 406
uterus	86%	76.19	147 / 170	56%	1.47	257 / 459
kidney	72%	59.28	64 / 89	57%	1.35	512 / 901
adipose	98%	91.39	1183 / 1204	0%	0	0 / 0
blood vessel	96%	91.01	1283 / 1335	0%	0	0 / 0
heart	65%	55.24	561 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	1.86	29 / 45
eye	0%	0	0 / 0	63%	1.69	50 / 80
muscle	56%	26.70	449 / 803	0%	0	0 / 0
spleen	45%	20.73	109 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	41%	0.80	12 / 29
peripheral blood	31%	114.98	291 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0006695	Biological process	cholesterol biosynthetic process
GO_0016125	Biological process	sterol metabolic process
GO_0050709	Biological process	negative regulation of protein secretion
GO_0006694	Biological process	steroid biosynthetic process
GO_1900222	Biological process	negative regulation of amyloid-beta clearance
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0008398	Molecular function	sterol 14-demethylase activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0005506	Molecular function	iron ion binding
GO_0020037	Molecular function	heme binding

Gene name	CYP51A1
Protein name	Cytochrome P450 family 51 subfamily A member 1 CYP51A1 protein Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)
Synonyms	CYP51
Description	FUNCTION: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis . Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis . Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL . .
Accessions	ENST00000450723.5 [Q16850-2] H7C0D0 ENST00000003100.13 [Q16850-1] Q16850 ENST00000422867.1 Q05D40 A0A8I5KRT9 ENST00000691309.1

CYP51A1 report