CYP4Z1 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	27% ± 4%	Explore
type I pneumocyte	3 studies	21% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP4Z1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	98%	609.76	448 / 459	72%	136.04	801 / 1118
lung	98%	149.61	565 / 578	18%	0.65	210 / 1155
esophagus	87%	63.03	1258 / 1445	11%	0.25	21 / 183
prostate	93%	120.69	227 / 245	5%	0.13	27 / 502
adipose	97%	180.40	1162 / 1204	0%	0	0 / 0
blood vessel	92%	67.44	1228 / 1335	0%	0	0 / 0
bladder	71%	43.33	15 / 21	20%	0.67	103 / 504
thymus	78%	48.35	510 / 653	3%	0.06	21 / 605
brain	75%	48.95	1977 / 2642	1%	0.01	4 / 705
muscle	72%	35.80	576 / 803	0%	0	0 / 0
heart	67%	35.97	577 / 861	0%	0	0 / 0
stomach	63%	26.09	226 / 359	3%	0.06	8 / 286
skin	64%	58.90	1162 / 1809	1%	0.02	3 / 472
uterus	36%	18.03	61 / 170	28%	1.37	128 / 459
liver	56%	28.80	126 / 226	4%	0.08	15 / 406
ovary	7%	3.41	13 / 180	52%	1.88	223 / 430
tonsil	0%	0	0 / 0	47%	1.28	21 / 45
kidney	40%	12.60	36 / 89	2%	0.03	15 / 901
intestine	36%	16.58	345 / 966	3%	0.05	14 / 527
adrenal gland	37%	16.75	96 / 258	0%	0.01	1 / 230
pancreas	6%	1.77	21 / 328	4%	0.20	7 / 178
spleen	1%	0.29	3 / 241	0%	0	0 / 0
peripheral blood	0%	0.09	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019369	Biological process	arachidonic acid metabolic process
GO_0048252	Biological process	lauric acid metabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005506	Molecular function	iron ion binding
GO_0008404	Molecular function	arachidonic acid 14,15-epoxygenase activity
GO_0020037	Molecular function	heme binding
GO_0070330	Molecular function	aromatase activity
GO_0052722	Molecular function	fatty acid in-chain hydroxylase activity

Gene name	CYP4Z1
Protein name	Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1) (Laurate 7-monooxygenase) (EC 1.14.14.130)
Synonyms	UNQ3060/PRO9882
Description	FUNCTION: A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .
Accessions	ENST00000334194.4 Q86W10

CYP4Z1 report