CYP4V2 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	5 studies	35% ± 10%	Explore
Mueller cell	4 studies	26% ± 5%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 9%	Explore
GABAergic neuron	3 studies	36% ± 8%	Explore
glutamatergic neuron	3 studies	38% ± 11%	Explore
oligodendrocyte	3 studies	17% ± 2%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	29% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2481.70	653 / 653	100%	14.99	602 / 605
brain	100%	1959.97	2638 / 2642	99%	10.32	697 / 705
liver	100%	7147.20	226 / 226	99%	22.27	400 / 406
kidney	100%	2908.36	89 / 89	98%	23.05	886 / 901
adrenal gland	100%	4295.14	258 / 258	98%	13.12	225 / 230
pancreas	100%	2240.83	328 / 328	97%	11.73	173 / 178
prostate	100%	1843.28	245 / 245	97%	9.68	486 / 502
stomach	99%	1302.45	355 / 359	95%	8.44	271 / 286
intestine	100%	2415.86	966 / 966	91%	7.73	482 / 527
breast	100%	1721.86	459 / 459	91%	10.33	1020 / 1118
lung	99%	1824.34	575 / 578	82%	6.97	948 / 1155
esophagus	95%	1810.32	1373 / 1445	85%	8.06	155 / 183
skin	85%	836.40	1535 / 1809	94%	15.41	442 / 472
bladder	100%	1830.10	21 / 21	77%	5.43	388 / 504
ovary	100%	1803.31	180 / 180	71%	4.59	306 / 430
uterus	100%	1720.11	170 / 170	65%	4.21	300 / 459
spleen	100%	2716.20	241 / 241	0%	0	0 / 0
blood vessel	100%	2272.33	1334 / 1335	0%	0	0 / 0
adipose	100%	1890.11	1203 / 1204	0%	0	0 / 0
heart	97%	1386.94	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	90%	16.29	72 / 80
lymph node	0%	0	0 / 0	83%	4.63	24 / 29
tonsil	0%	0	0 / 0	58%	3.73	26 / 45
muscle	54%	322.08	436 / 803	0%	0	0 / 0
peripheral blood	32%	204.17	298 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007601	Biological process	visual perception
GO_0001523	Biological process	retinoid metabolic process
GO_0010430	Biological process	fatty acid omega-oxidation
GO_0016125	Biological process	sterol metabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0102033	Molecular function	long-chain fatty acid omega-hydroxylase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0020037	Molecular function	heme binding

Gene name	CYP4V2
Protein name	Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4V2 protein
Synonyms
Description	FUNCTION: A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs . Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). .
Accessions	Q49AA5 ENST00000378802.5 [Q6ZWL3-1] Q6ZWL3

CYP4V2 report