CYP4F8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP4F8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP4F8 at tissue level.

III. Associated gene sets

GO_0006690Biological processicosanoid metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0018685Molecular functionalkane 1-monooxygenase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0070330Molecular functionaromatase activity

IV. Literature review

[source]
Gene nameCYP4F8
Protein nameCytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)
Cytochrome P450 family 4 subfamily F member 8
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions . Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) . Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 . Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids . Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4. .

AccessionsENST00000612078.5
ENST00000589722.2
A0A087WUC9
ENST00000325723.10
A0A087WVG9
P98187
A0A087WZJ1
ENST00000617645.4