CYP4A11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP4A11 at tissue level.

III. Associated gene sets

GO_0032305Biological processpositive regulation of icosanoid secretion
GO_0043651Biological processlinoleic acid metabolic process
GO_0003091Biological processrenal water homeostasis
GO_0046456Biological processicosanoid biosynthetic process
GO_0055078Biological processsodium ion homeostasis
GO_0001822Biological processkidney development
GO_0048252Biological processlauric acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0036101Biological processleukotriene B4 catabolic process
GO_0003095Biological processpressure natriuresis
GO_0097267Biological processomega-hydroxylase P450 pathway
GO_0019373Biological processepoxygenase P450 pathway
GO_0006691Biological processleukotriene metabolic process
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0031408Biological processoxylipin biosynthetic process
GO_0016324Cellular componentapical plasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0018685Molecular functionalkane 1-monooxygenase activity
GO_0070330Molecular functionaromatase activity
GO_0050051Molecular functionleukotriene-B4 20-monooxygenase activity
GO_0008391Molecular functionarachidonic acid monooxygenase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0102033Molecular functionlong-chain fatty acid omega-hydroxylase activity
GO_0008392Molecular functionarachidonic acid epoxygenase activity

IV. Literature review

[source]
Gene nameCYP4A11
Protein nameCytochrome P450 family 4 subfamily A member 11
Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
SynonymsCYP4A2
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid . Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver . Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure . Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency . May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening . Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer . Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids . Has little activity toward prostaglandins A1 and E1 . .

AccessionsENST00000468629.5
V9GZ77
V9GYC6
ENST00000474458.5
V9GYQ2
A0A0C4DFV7
ENST00000462347.5
ENST00000371905.1
ENST00000465874.5
Q02928
V9GY41
ENST00000310638.9 [Q02928-1]
V9GYK4
ENST00000475477.5