CYP3A7 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP3A7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1074.90	226 / 226	80%	29.50	323 / 406
kidney	94%	30.01	84 / 89	12%	0.39	110 / 901
lung	95%	31.78	548 / 578	1%	0.02	15 / 1155
breast	82%	90.96	378 / 459	1%	0.01	6 / 1118
adrenal gland	73%	19.67	188 / 258	7%	0.31	15 / 230
prostate	72%	13.35	176 / 245	1%	0.01	4 / 502
pancreas	64%	8.41	210 / 328	2%	0.02	3 / 178
intestine	61%	7.43	594 / 966	1%	0.03	7 / 527
skin	59%	5.44	1069 / 1809	1%	0.02	4 / 472
bladder	52%	2.57	11 / 21	5%	0.21	23 / 504
ovary	51%	7.52	92 / 180	0%	0	0 / 430
uterus	49%	19.03	83 / 170	1%	0.01	4 / 459
esophagus	45%	5.06	656 / 1445	1%	0.15	2 / 183
stomach	33%	2.07	120 / 359	1%	0.04	4 / 286
adipose	31%	3.89	372 / 1204	0%	0	0 / 0
thymus	24%	1.65	159 / 653	0%	0.00	1 / 605
blood vessel	20%	1.16	270 / 1335	0%	0	0 / 0
heart	18%	0.95	152 / 861	0%	0	0 / 0
peripheral blood	12%	1.20	114 / 929	0%	0	0 / 0
brain	11%	0.54	282 / 2642	0%	0.00	1 / 705
spleen	8%	0.61	19 / 241	0%	0	0 / 0
muscle	5%	0.20	39 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006805	Biological process	xenobiotic metabolic process
GO_0042573	Biological process	retinoic acid metabolic process
GO_0006694	Biological process	steroid biosynthetic process
GO_0042572	Biological process	retinol metabolic process
GO_0002933	Biological process	lipid hydroxylation
GO_0008210	Biological process	estrogen metabolic process
GO_0070989	Biological process	oxidative demethylation
GO_0008202	Biological process	steroid metabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070330	Molecular function	aromatase activity
GO_0062183	Molecular function	all-trans retinoic acid 18-hydroxylase activity
GO_0101020	Molecular function	estrogen 16-alpha-hydroxylase activity
GO_0019825	Molecular function	oxygen binding
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0008401	Molecular function	retinoic acid 4-hydroxylase activity
GO_0020037	Molecular function	heme binding
GO_0050649	Molecular function	testosterone 6-beta-hydroxylase activity
GO_0008395	Molecular function	steroid hydroxylase activity
GO_0101021	Molecular function	estrogen 2-hydroxylase activity

Gene name	CYP3A7
Protein name	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) Cytochrome P450 variant 3A7
Synonyms
Description	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones . Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position . Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development . Also involved in the oxidative metabolism of xenobiotics including anticonvulsants . .
Accessions	Q6KGV3 P24462 ENST00000336374.4 [P24462-1]

CYP3A7 report