CYP39A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP39A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP39A1 at tissue level.

III. Associated gene sets

GO_0006699Biological processbile acid biosynthetic process
GO_0016125Biological processsterol metabolic process
GO_0042632Biological processcholesterol homeostasis
GO_0006707Biological processcholesterol catabolic process
GO_0007586Biological processdigestion
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033782Molecular function24-hydroxycholesterol 7alpha-hydroxylase activity
GO_0005506Molecular functioniron ion binding
GO_0008396Molecular functionoxysterol 7-alpha-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0008387Molecular functionsteroid 7-alpha-hydroxylase activity

IV. Literature review

[source]
Gene nameCYP39A1
Protein nameCytochrome P450 family 39 subfamily A member 1
24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis . Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsQ9NYL5
A0A087WTD2
ENST00000619708.4
ENST00000275016.3