CYP2W1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2W1 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_1903604Biological processcytochrome metabolic process
GO_0046222Biological processaflatoxin metabolic process
GO_0006082Biological processorganic acid metabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0034653Biological processretinoic acid catabolic process
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0001972Molecular functionretinoic acid binding
GO_0005503Molecular functionall-trans retinal binding
GO_1904768Molecular functionall-trans-retinol binding

IV. Literature review

[source]
Gene nameCYP2W1
Protein nameCytochrome P450 family 2 subfamily W member 1
Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism . Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates . Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) . Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids . May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsH7C015
ENST00000415893.1
ENST00000340150.10
A6NJ10
ENST00000308919.12
Q8TAV3