CYP2U1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006082Biological processorganic acid metabolic process
GO_1903604Biological processcytochrome metabolic process
GO_0097267Biological processomega-hydroxylase P450 pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0102033Molecular functionlong-chain fatty acid omega-hydroxylase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0052869Molecular functionarachidonic acid omega-hydroxylase activity
GO_0008395Molecular functionsteroid hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

IV. Literature review

[source]
Gene nameCYP2U1
Protein nameCytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
Cytochrome P450 (EC 1.14.14.-)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes . May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin . .

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .

AccessionsENST00000332884.11 [Q7Z449-1]
Q7Z449
ENST00000508453.1
E9PGH5