Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 7 studies | 25% ± 9% | |
| astrocyte | 5 studies | 25% ± 6% | |
| cardiac muscle cell | 4 studies | 22% ± 5% | |
| epithelial cell | 3 studies | 21% ± 5% | |
| enterocyte | 3 studies | 20% ± 4% | |
| oligodendrocyte precursor cell | 3 studies | 22% ± 6% |
Insufficient scRNA-seq data for expression of CYP2J2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 3701.45 | 226 / 226 | 94% | 62.00 | 382 / 406 |
| brain | 99% | 1311.04 | 2612 / 2642 | 85% | 20.50 | 599 / 705 |
| intestine | 49% | 1118.34 | 472 / 966 | 91% | 29.37 | 480 / 527 |
| bladder | 52% | 679.52 | 11 / 21 | 81% | 33.24 | 410 / 504 |
| prostate | 44% | 176.79 | 109 / 245 | 82% | 21.16 | 413 / 502 |
| stomach | 39% | 154.15 | 141 / 359 | 76% | 21.86 | 218 / 286 |
| breast | 38% | 189.80 | 176 / 459 | 71% | 14.08 | 794 / 1118 |
| skin | 69% | 614.32 | 1251 / 1809 | 34% | 4.49 | 160 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 16.17 | 1 / 1 |
| heart | 98% | 4815.40 | 842 / 861 | 0% | 0 | 0 / 0 |
| esophagus | 39% | 457.59 | 559 / 1445 | 50% | 7.21 | 92 / 183 |
| muscle | 80% | 878.48 | 641 / 803 | 0% | 0 | 0 / 0 |
| kidney | 19% | 77.76 | 17 / 89 | 56% | 103.48 | 505 / 901 |
| pancreas | 8% | 21.35 | 26 / 328 | 65% | 16.45 | 115 / 178 |
| lung | 15% | 77.93 | 89 / 578 | 50% | 6.68 | 575 / 1155 |
| uterus | 4% | 13.52 | 6 / 170 | 49% | 9.49 | 227 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 44% | 4.77 | 20 / 45 |
| ovary | 0% | 0 | 0 / 180 | 35% | 4.10 | 149 / 430 |
| eye | 0% | 0 | 0 / 0 | 13% | 1.13 | 10 / 80 |
| adipose | 12% | 48.82 | 141 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0.90 | 1 / 258 | 6% | 2.50 | 14 / 230 |
| blood vessel | 2% | 16.08 | 21 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 3.12 | 9 / 929 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.49 | 1 / 653 | 1% | 0.11 | 4 / 605 |
| spleen | 0% | 4.89 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0043651 | Biological process | linoleic acid metabolic process |
| GO_0006690 | Biological process | icosanoid metabolic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0019373 | Biological process | epoxygenase P450 pathway |
| GO_0006082 | Biological process | organic acid metabolic process |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0106255 | Molecular function | hydroperoxy icosatetraenoate isomerase activity |
| GO_0106301 | Molecular function | arachidonic acid 5,6-epoxygenase activity |
| GO_0016712 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO_0008404 | Molecular function | arachidonic acid 14,15-epoxygenase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0016853 | Molecular function | isomerase activity |
| GO_0008405 | Molecular function | arachidonic acid 11,12-epoxygenase activity |
| GO_0071614 | Molecular function | linoleic acid epoxygenase activity |
| GO_0008392 | Molecular function | arachidonic acid epoxygenase activity |
| Gene name | CYP2J2 |
| Protein name | Cytochrome P450 2J2 (EC 1.14.14.-) (Albendazole monooxygenase (hydroxylating)) (EC 1.14.14.74) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Arachidonic acid epoxygenase) (CYPIIJ2) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) Cytochrome P450 epoxygenase Cytochrome P450 family 2 subfamily J member 2 Cytochrome P450 Cytochrome P450 family 2 subfamily J member 2 (Cytochrome P450, family 2, subfamily J, polypeptide 2, isoform CRA_c) |
| Synonyms | hCG_22170 |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of PUFA . Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools . In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent . Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone . Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole . Catalyzes the sulfoxidation of fenbedazole . . |
| Accessions | P51589 Q9UN91 A0A3B3IU95 Q96RX4 ENST00000466095.5 ENST00000371204.4 A0A3B3ITF2 ENST00000468257.2 ENST00000469406.6 A0A3B3IT99 |
