I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 74% ± 25% | |
| glutamatergic neuron | 3 studies | 27% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 74% ± 25% | |
| glutamatergic neuron | 3 studies | 27% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 4 studies | 42% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 223351.69 | 226 / 226 | 90% | 648.02 | 366 / 406 |
| brain | 95% | 534.14 | 2506 / 2642 | 55% | 1.30 | 389 / 705 |
| esophagus | 97% | 579.52 | 1398 / 1445 | 37% | 2.29 | 67 / 183 |
| pancreas | 100% | 542.52 | 328 / 328 | 30% | 0.79 | 54 / 178 |
| uterus | 99% | 376.91 | 168 / 170 | 31% | 1.26 | 142 / 459 |
| prostate | 99% | 420.78 | 242 / 245 | 22% | 0.37 | 110 / 502 |
| ovary | 96% | 296.36 | 172 / 180 | 23% | 0.42 | 101 / 430 |
| stomach | 97% | 389.16 | 350 / 359 | 16% | 0.83 | 45 / 286 |
| thymus | 95% | 312.33 | 621 / 653 | 16% | 0.25 | 97 / 605 |
| lung | 87% | 185.42 | 502 / 578 | 20% | 0.53 | 226 / 1155 |
| breast | 91% | 242.88 | 416 / 459 | 14% | 0.31 | 159 / 1118 |
| bladder | 95% | 255.24 | 20 / 21 | 9% | 0.25 | 44 / 504 |
| kidney | 92% | 288.09 | 82 / 89 | 10% | 0.32 | 94 / 901 |
| adrenal gland | 91% | 198.02 | 235 / 258 | 10% | 0.18 | 23 / 230 |
| intestine | 89% | 259.94 | 856 / 966 | 9% | 1.39 | 49 / 527 |
| spleen | 96% | 608.59 | 231 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 94% | 228.05 | 1254 / 1335 | 0% | 0 | 0 / 0 |
| skin | 75% | 598.32 | 1358 / 1809 | 7% | 0.18 | 33 / 472 |
| adipose | 80% | 168.23 | 959 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 3.67 | 30 / 45 |
| muscle | 66% | 101.61 | 531 / 803 | 0% | 0 | 0 / 0 |
| heart | 43% | 63.16 | 371 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 25% | 242.17 | 234 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.05 | 3 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0042197 | Biological process | halogenated hydrocarbon metabolic process |
| GO_0009617 | Biological process | response to bacterium |
| GO_0016098 | Biological process | monoterpenoid metabolic process |
| GO_0019373 | Biological process | epoxygenase P450 pathway |
| GO_0018885 | Biological process | carbon tetrachloride metabolic process |
| GO_0001676 | Biological process | long-chain fatty acid metabolic process |
| GO_0002933 | Biological process | lipid hydroxylation |
| GO_0042759 | Biological process | long-chain fatty acid biosynthetic process |
| GO_0018910 | Biological process | benzene metabolic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0018960 | Biological process | 4-nitrophenol metabolic process |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0018601 | Molecular function | 4-nitrophenol 2-monooxygenase activity |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0016709 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO_0070330 | Molecular function | aromatase activity |
| GO_0051879 | Molecular function | Hsp90 protein binding |
| GO_0016712 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO_0120319 | Molecular function | long-chain fatty acid omega-1 hydroxylase activity |
| GO_0019825 | Molecular function | oxygen binding |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0030544 | Molecular function | Hsp70 protein binding |
| GO_0008392 | Molecular function | arachidonic acid epoxygenase activity |
| Gene name | CYP2E1 |
| Protein name | unspecific monooxygenase (EC 1.14.14.1) Cytochrome P450IIE1 Cytochrome P450 2E1 (EC 1.14.13.n7) (EC 1.14.14.1) Cytochrome P450 family 2 subfamily E member 1 Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) CYP2E1 protein Cytochrome P450 2E1 |
| Synonyms | CYP2E |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids . May be involved in the oxidative metabolism of xenobiotics (Probable). . FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. . FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. . |
| Accessions | F5H694 H0Y7H4 ENST00000418356.1 Q4LBD0 Q573H0 Q573G9 P05181 Q6NWT7 H0YGV5 ENST00000463117.6 ENST00000541080.5 ENST00000252945.8 H0Y593 ENST00000421586.5 Q16868 ENST00000541261.1 Q6LER5 |
