CYP2D7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP2D7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2D7 at tissue level.

III. Associated gene sets

GO_0042178Biological processxenobiotic catabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0070330Molecular functionaromatase activity
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

IV. Literature review

[source]
Gene nameCYP2D7
Protein nameCytochrome P450 (EC 1.14.14.-)
Cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) (Putative cytochrome P450 2D7)
Putative cytochrome P450 2D7
Putative cytochrome P450 2D7 (EC 1.14.14.1)
Synonyms
DescriptionFUNCTION: May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine . However, another study could not confirm it . .

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .

AccessionsENST00000635668.1
F5H6E7
ENST00000635135.1
A0A087X1C5
A0A0U1RRC6
ENST00000435101.1
A0A0U1RQD0
ENST00000634782.1
ENST00000618719.2