I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 81% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 81% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 4 studies | 37% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 47461.23 | 226 / 226 | 97% | 244.86 | 395 / 406 |
| kidney | 94% | 335.27 | 84 / 89 | 35% | 2.14 | 317 / 901 |
| stomach | 77% | 1204.14 | 276 / 359 | 38% | 1.85 | 109 / 286 |
| esophagus | 40% | 218.19 | 571 / 1445 | 50% | 2.63 | 92 / 183 |
| pancreas | 16% | 16.18 | 53 / 328 | 73% | 7.63 | 130 / 178 |
| intestine | 46% | 660.75 | 440 / 966 | 30% | 2.00 | 158 / 527 |
| skin | 57% | 61.13 | 1030 / 1809 | 0% | 0.02 | 2 / 472 |
| lung | 18% | 12.23 | 105 / 578 | 24% | 0.99 | 272 / 1155 |
| bladder | 5% | 6.62 | 1 / 21 | 16% | 1.28 | 83 / 504 |
| uterus | 4% | 6.02 | 7 / 170 | 14% | 0.80 | 65 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.33 | 7 / 45 |
| peripheral blood | 9% | 26.12 | 87 / 929 | 0% | 0 | 0 / 0 |
| breast | 6% | 7.26 | 28 / 459 | 1% | 0.02 | 11 / 1118 |
| adipose | 6% | 8.24 | 70 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 1% | 0.97 | 9 / 653 | 2% | 0.07 | 10 / 605 |
| ovary | 1% | 0.41 | 2 / 180 | 1% | 0.02 | 5 / 430 |
| adrenal gland | 1% | 0.89 | 3 / 258 | 0% | 0.00 | 1 / 230 |
| spleen | 1% | 68.23 | 3 / 241 | 0% | 0 | 0 / 0 |
| prostate | 1% | 0.37 | 2 / 245 | 0% | 0.01 | 2 / 502 |
| blood vessel | 1% | 1.09 | 12 / 1335 | 0% | 0 | 0 / 0 |
| brain | 1% | 0.41 | 16 / 2642 | 0% | 0.00 | 1 / 705 |
| heart | 0% | 1.21 | 4 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.28 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0043603 | Biological process | amide metabolic process |
| GO_0046456 | Biological process | icosanoid biosynthetic process |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0016098 | Biological process | monoterpenoid metabolic process |
| GO_0097267 | Biological process | omega-hydroxylase P450 pathway |
| GO_0019373 | Biological process | epoxygenase P450 pathway |
| GO_0042178 | Biological process | xenobiotic catabolic process |
| GO_0008210 | Biological process | estrogen metabolic process |
| GO_0042759 | Biological process | long-chain fatty acid biosynthetic process |
| GO_0070989 | Biological process | oxidative demethylation |
| GO_0032787 | Biological process | monocarboxylic acid metabolic process |
| GO_0019627 | Biological process | urea metabolic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0018675 | Molecular function | (S)-limonene 6-monooxygenase activity |
| GO_0070330 | Molecular function | aromatase activity |
| GO_0052741 | Molecular function | (R)-limonene 6-monooxygenase activity |
| GO_0016712 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO_0008404 | Molecular function | arachidonic acid 14,15-epoxygenase activity |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0034875 | Molecular function | caffeine oxidase activity |
| GO_0018676 | Molecular function | (S)-limonene 7-monooxygenase activity |
| GO_0008405 | Molecular function | arachidonic acid 11,12-epoxygenase activity |
| GO_0008392 | Molecular function | arachidonic acid epoxygenase activity |
| GO_0008395 | Molecular function | steroid hydroxylase activity |
| Gene name | CYP2C9 |
| Protein name | Cytochrome P-450 2C Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) Cytochrome P450 (EC 1.14.14.51) unspecific monooxygenase (EC 1.14.14.1) Cytochrome P450 family 2 subfamily C polypeptide 9 Cytochrome P450 (EC 1.14.13.48) Cytochrome P450 2C9 Cytochrome P450 family 2 subfamily C member 9 Cytochrome p4502C9 Cytochrome P450 |
| Synonyms | CYP2C10 |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis . Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 . Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) . Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol . Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan . . |
| Accessions | A0A2H4QWS7 A0A7D5UNI7 A0A1X9PW73 A0A2H4QWJ3 A0A2H4QWT3 A0A2H4QWR6 A0A345FZQ8 A0A345FZQ9 P11712 S5RV20 A0A866U6Z0 A0A2D1BLU4 A0A7D5UNN1 A0A2R8YF67 Q5EDC5 Q9UQ59 A0A866U7A7 S5R8H1 S5RV29 A0A2H4QWV3 A0A2H4QWR7 A0A7D5YZ42 A0A1X9PW33 A0A1X9PWD6 A0A2H4QWU8 Q9UEH3 A0A0A7MAK0 ENST00000643112.1 S5RXA4 A0A7D5YZN0 A0A1X9PW77 A0A2H4QWQ3 A0A866U5P9 A0A2H4QWU9 A0A2H4QWL2 S5RG22 A0A1X9PW57 A0A1X9PW55 A0A2H4QWU1 ENST00000461906.1 [P11712-2] A0A2H4QWT6 ENST00000260682.8 [P11712-1] S5R8G8 A0A1X9PWC6 A0A2H4QWU7 A0A7D5YV17 A0A2D1BIX4 A0A2H4QWR8 |
