CYP2C19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP2C19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2C19 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0016098Biological processmonoterpenoid metabolic process
GO_0097267Biological processomega-hydroxylase P450 pathway
GO_0019373Biological processepoxygenase P450 pathway
GO_0042178Biological processxenobiotic catabolic process
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0008202Biological processsteroid metabolic process
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0019899Molecular functionenzyme binding
GO_0018675Molecular function(S)-limonene 6-monooxygenase activity
GO_0070330Molecular functionaromatase activity
GO_0052741Molecular function(R)-limonene 6-monooxygenase activity
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0120319Molecular functionlong-chain fatty acid omega-1 hydroxylase activity
GO_0019825Molecular functionoxygen binding
GO_0016491Molecular functionoxidoreductase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0018676Molecular function(S)-limonene 7-monooxygenase activity
GO_0008392Molecular functionarachidonic acid epoxygenase activity
GO_0008395Molecular functionsteroid hydroxylase activity

IV. Literature review

[source]
Gene nameCYP2C19
Protein nameCytochrome P450
Cytochrome P450 family 2 subfamily C polypeptide 19
Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
Cytochrome P450 family 2 subfamily C member 19
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position . Catalyzes the epoxidation of double bonds of PUFA . Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol . Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position . .

AccessionsB0ZDM8
ENST00000480405.2
A0A087X125
A0A2D1BPP2
A0A2D1BII0
Q767A3
P33261
ENST00000371321.9