CYP2C18 | OmnibusX

Name	Number of supported studies	Average coverage
enterocyte	3 studies	22% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2C18 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	5476.00	226 / 226	90%	38.95	367 / 406
stomach	70%	1275.84	250 / 359	59%	7.95	170 / 286
esophagus	39%	1137.32	565 / 1445	69%	11.71	127 / 183
intestine	39%	616.93	374 / 966	59%	5.47	310 / 527
pancreas	5%	8.11	16 / 328	80%	14.93	142 / 178
tonsil	0%	0	0 / 0	73%	9.88	33 / 45
skin	68%	305.49	1223 / 1809	2%	0.06	8 / 472
lung	5%	7.13	31 / 578	50%	5.46	576 / 1155
uterus	1%	21.32	2 / 170	36%	3.57	163 / 459
bladder	0%	0	0 / 21	29%	2.34	145 / 504
kidney	1%	1.43	1 / 89	3%	0.20	27 / 901
peripheral blood	2%	4.43	16 / 929	0%	0	0 / 0
thymus	0%	0	0 / 653	1%	0.07	9 / 605
breast	0%	1.66	2 / 459	1%	0.03	7 / 1118
ovary	0%	0	0 / 180	1%	0.04	3 / 430
adipose	0%	1.21	5 / 1204	0%	0	0 / 0
spleen	0%	9.00	1 / 241	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0.01	1 / 502
muscle	0%	0.26	1 / 803	0%	0	0 / 0
heart	0%	0.12	1 / 861	0%	0	0 / 0
blood vessel	0%	0.09	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
bone marrow	0%	0	0 / 0	0%	0	0 / 0
brain	0%	0	0 / 2642	0%	0	0 / 705
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019373	Biological process	epoxygenase P450 pathway
GO_0006805	Biological process	xenobiotic metabolic process
GO_0043651	Biological process	linoleic acid metabolic process
GO_0042573	Biological process	retinoic acid metabolic process
GO_0042572	Biological process	retinol metabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005737	Cellular component	cytoplasm
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0019825	Molecular function	oxygen binding
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0008392	Molecular function	arachidonic acid epoxygenase activity
GO_0071614	Molecular function	linoleic acid epoxygenase activity
GO_0008401	Molecular function	retinoic acid 4-hydroxylase activity
GO_0020037	Molecular function	heme binding
GO_0070330	Molecular function	aromatase activity
GO_0016712	Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Gene name	CYP2C18
Protein name	Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) unspecific monooxygenase (EC 1.14.14.1)
Synonyms
Description	FUNCTION: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). .
Accessions	Q2XN56 ENST00000339022.6 [P33260-2] ENST00000285979.11 [P33260-1] P33260

CYP2C18 report