I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 64% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 64% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 28% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 23512.16 | 226 / 226 | 88% | 74.64 | 357 / 406 |
| intestine | 63% | 368.45 | 607 / 966 | 73% | 24.95 | 387 / 527 |
| kidney | 99% | 966.00 | 88 / 89 | 2% | 0.23 | 21 / 901 |
| stomach | 8% | 1.97 | 30 / 359 | 67% | 24.90 | 192 / 286 |
| lung | 48% | 10.85 | 275 / 578 | 9% | 2.98 | 103 / 1155 |
| pancreas | 19% | 2.36 | 62 / 328 | 18% | 2.41 | 32 / 178 |
| esophagus | 6% | 2.79 | 81 / 1445 | 30% | 10.11 | 55 / 183 |
| bladder | 5% | 0.29 | 1 / 21 | 23% | 7.39 | 114 / 504 |
| peripheral blood | 17% | 7.67 | 157 / 929 | 0% | 0 | 0 / 0 |
| uterus | 10% | 1.90 | 17 / 170 | 6% | 1.12 | 26 / 459 |
| skin | 12% | 3.85 | 222 / 1809 | 0% | 0.03 | 1 / 472 |
| prostate | 11% | 1.68 | 28 / 245 | 0% | 0.01 | 1 / 502 |
| ovary | 9% | 0.92 | 17 / 180 | 0% | 0.04 | 1 / 430 |
| spleen | 10% | 4.92 | 23 / 241 | 0% | 0 | 0 / 0 |
| breast | 6% | 2.11 | 28 / 459 | 2% | 0.23 | 26 / 1118 |
| adrenal gland | 7% | 0.96 | 17 / 258 | 0% | 0 | 0 / 230 |
| adipose | 6% | 1.33 | 72 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 5% | 0.77 | 62 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 4% | 0.75 | 28 / 653 | 0% | 0 | 0 / 605 |
| muscle | 3% | 0.37 | 27 / 803 | 0% | 0 | 0 / 0 |
| heart | 3% | 0.38 | 28 / 861 | 0% | 0 | 0 / 0 |
| brain | 2% | 0.60 | 63 / 2642 | 0% | 0.01 | 1 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0019373 | Biological process | epoxygenase P450 pathway |
| GO_0042178 | Biological process | xenobiotic catabolic process |
| GO_0042180 | Biological process | cellular ketone metabolic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0016712 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO_0062189 | Molecular function | anandamide 14,15 epoxidase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0062187 | Molecular function | anandamide 8,9 epoxidase activity |
| GO_0062184 | Molecular function | testosterone 16-beta-hydroxylase activity |
| GO_0008390 | Molecular function | testosterone 16-alpha-hydroxylase activity |
| GO_0008392 | Molecular function | arachidonic acid epoxygenase activity |
| GO_0062188 | Molecular function | anandamide 11,12 epoxidase activity |
| GO_0101021 | Molecular function | estrogen 2-hydroxylase activity |
| Gene name | CYP2B6 |
| Protein name | Cytochrome P450 Cytochrome P450 (EC 1.14.14.1) Cytochrome P450 family 2 subfamily B member 6 Cytochrome P450 2B6 (EC 1.14.14.1) Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1) |
| Synonyms | |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 . Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs . Acts as a 1,4-cineole 2-exo-monooxygenase . .; FUNCTION: Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . |
| Accessions | Q6NWU1 ENST00000598834.2 Q6NWU2 Q9UNX8 F2X1A7 P20813 ENST00000593831.1 A0A2R8YFA4 M0QZJ2 F2X1B0 ENST00000324071.10 [P20813-1] |
