CYP2A6 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	5 studies	47% ± 25%	Explore
endothelial cell	3 studies	16% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2A6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	40904.56	226 / 226	87%	753.13	355 / 406
breast	99%	64.45	453 / 459	34%	88.08	380 / 1118
lung	95%	58.16	548 / 578	17%	4.40	198 / 1155
brain	88%	14.01	2336 / 2642	23%	0.47	165 / 705
uterus	99%	61.91	168 / 170	12%	0.69	56 / 459
prostate	97%	30.59	237 / 245	13%	0.23	63 / 502
ovary	99%	78.80	179 / 180	9%	0.23	40 / 430
adrenal gland	95%	38.30	246 / 258	13%	0.52	30 / 230
bladder	95%	34.81	20 / 21	7%	0.34	36 / 504
ureter	0%	0	0 / 0	100%	1.22	1 / 1
adipose	96%	39.52	1156 / 1204	0%	0	0 / 0
intestine	78%	13.41	756 / 966	2%	1.09	12 / 527
esophagus	63%	8.00	908 / 1445	15%	1.30	28 / 183
muscle	76%	9.67	614 / 803	0%	0	0 / 0
thymus	74%	10.18	484 / 653	1%	0.02	6 / 605
skin	72%	10.88	1297 / 1809	3%	0.06	12 / 472
blood vessel	70%	10.04	937 / 1335	0%	0	0 / 0
spleen	65%	20.54	157 / 241	0%	0	0 / 0
stomach	50%	5.04	180 / 359	8%	0.24	22 / 286
pancreas	40%	3.88	131 / 328	9%	0.19	16 / 178
heart	48%	5.14	415 / 861	0%	0	0 / 0
peripheral blood	36%	5.28	336 / 929	0%	0	0 / 0
kidney	24%	2.06	21 / 89	2%	1.10	15 / 901
tonsil	0%	0	0 / 0	4%	0.64	2 / 45
lymph node	0%	0	0 / 0	3%	0.05	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0019373	Biological process	epoxygenase P450 pathway
GO_0042178	Biological process	xenobiotic catabolic process
GO_0046226	Biological process	coumarin catabolic process
GO_0006805	Biological process	xenobiotic metabolic process
GO_0008202	Biological process	steroid metabolic process
GO_0009804	Biological process	coumarin metabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005737	Cellular component	cytoplasm
GO_0005881	Cellular component	cytoplasmic microtubule
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0019899	Molecular function	enzyme binding
GO_0008389	Molecular function	coumarin 7-hydroxylase activity
GO_0005506	Molecular function	iron ion binding
GO_0008392	Molecular function	arachidonic acid epoxygenase activity
GO_0020037	Molecular function	heme binding
GO_0016712	Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Gene name	CYP2A6
Protein name	Cytochrome P450 family 2 subfamily A member 6 Cytochrome P450 2A6 (EC 1.14.14.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
Synonyms	CYP2A3
Description	FUNCTION: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. .
Accessions	P11509 ENST00000600495.1 ENST00000301141.10 M0R2Z4

CYP2A6 report