CYP27C1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP27C1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	93%	225.52	158 / 170	63%	5.03	291 / 459
bladder	95%	282.29	20 / 21	43%	2.82	219 / 504
esophagus	73%	138.44	1052 / 1445	49%	4.02	90 / 183
skin	78%	481.26	1420 / 1809	40%	2.27	188 / 472
intestine	93%	203.57	896 / 966	8%	0.23	44 / 527
prostate	99%	223.44	242 / 245	1%	0.03	7 / 502
ureter	0%	0	0 / 0	100%	1.94	1 / 1
adipose	89%	140.74	1069 / 1204	0%	0	0 / 0
breast	68%	72.58	314 / 459	16%	0.79	175 / 1118
brain	19%	27.24	501 / 2642	64%	2.34	449 / 705
tonsil	0%	0	0 / 0	76%	5.82	34 / 45
pancreas	3%	1.59	10 / 328	63%	2.49	112 / 178
kidney	46%	38.07	41 / 89	13%	0.54	116 / 901
lung	14%	10.19	80 / 578	44%	2.18	506 / 1155
heart	54%	83.49	465 / 861	0%	0	0 / 0
stomach	43%	55.89	156 / 359	8%	0.16	22 / 286
ovary	39%	43.19	71 / 180	5%	0.09	23 / 430
adrenal gland	31%	30.22	79 / 258	13%	0.34	29 / 230
thymus	27%	17.80	179 / 653	8%	0.29	49 / 605
liver	19%	12.64	42 / 226	11%	0.25	46 / 406
spleen	29%	18.61	70 / 241	0%	0	0 / 0
blood vessel	29%	26.50	387 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	21%	0.46	17 / 80
muscle	7%	4.24	53 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
peripheral blood	0%	0.10	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0042574	Biological process	retinal metabolic process
GO_0042573	Biological process	retinoic acid metabolic process
GO_0042572	Biological process	retinol metabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0031966	Cellular component	mitochondrial membrane
GO_0005739	Cellular component	mitochondrion
GO_0061897	Molecular function	all-trans retinal 3,4-desaturase activity
GO_1904768	Molecular function	all-trans-retinol binding
GO_0061898	Molecular function	all-trans retinoic acid 3,4-desaturase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0005503	Molecular function	all-trans retinal binding
GO_0061896	Molecular function	all-trans retinol 3,4-desaturase activity
GO_0005502	Molecular function	11-cis retinal binding
GO_0020037	Molecular function	heme binding
GO_0001972	Molecular function	retinoic acid binding
GO_0061899	Molecular function	11-cis-retinal 3,4-desaturase activity

Gene name	CYP27C1
Protein name	Cytochrome P450 family 27 subfamily C member 1 Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase)
Synonyms
Description	FUNCTION: [Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). .
Accessions	ENST00000335247.11 [Q4G0S4-1] A0A7N4I3A3 ENST00000409327.2 [Q4G0S4-1] ENST00000664447.2 Q4G0S4

CYP27C1 report