CYP26C1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP26C1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP26C1 at tissue level.

III. Associated gene sets

GO_0048284Biological processorganelle fusion
GO_0034653Biological processretinoic acid catabolic process
GO_0006766Biological processvitamin metabolic process
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0016125Biological processsterol metabolic process
GO_0014032Biological processneural crest cell development
GO_0009952Biological processanterior/posterior pattern specification
GO_0007417Biological processcentral nervous system development
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0070330Molecular functionaromatase activity
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameCYP26C1
Protein nameCytochrome P450 26C1 (CYP26C1) (EC 1.14.14.1)
Cytochrome P450 family 26 subfamily C member 1 (Cytochrome P450, family 26, subfamily C, polypeptide 1, isoform CRA_a)
SynonymshCG_39535
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals . RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 . Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling (Probable). Able to metabolize other RAs such as 9-cis with high efficiency . Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole . In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (By similarity). .

AccessionsA0A096LNL5
ENST00000651965.1
Q6V0L0
ENST00000624358.3