CYP26A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP26A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP26A1 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006766Biological processvitamin metabolic process
GO_0001822Biological processkidney development
GO_0033189Biological processresponse to vitamin A
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0016125Biological processsterol metabolic process
GO_0042573Biological processretinoic acid metabolic process
GO_0032526Biological processresponse to retinoic acid
GO_0034653Biological processretinoic acid catabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016709Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0062183Molecular functionall-trans retinoic acid 18-hydroxylase activity
GO_0062182Molecular functionall-trans retinoic acid 4-hydrolase activity
GO_0019825Molecular functionoxygen binding
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameCYP26A1
Protein nameCytochrome P450 family 26 subfamily A member 1
Cytochrome P450 26A1 (CYP26A1) (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
SynonymsCYP26
P450RAI1
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals . RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling . Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) . Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid . .

AccessionsENST00000371531.5 [O43174-2]
ENST00000624589.3
O43174
ENST00000224356.5 [O43174-1]
A0A096LNN2