CYP24A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP24A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP24A1 at tissue level.

III. Associated gene sets

GO_0070561Biological processvitamin D receptor signaling pathway
GO_0006766Biological processvitamin metabolic process
GO_0042369Biological processvitamin D catabolic process
GO_0033280Biological processresponse to vitamin D
GO_0001649Biological processosteoblast differentiation
GO_0042359Biological processvitamin D metabolic process
GO_0005743Cellular componentmitochondrial inner membrane
GO_0062181Molecular function1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
GO_0030342Molecular function1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
GO_0005506Molecular functioniron ion binding
GO_0070643Molecular functionvitamin D 25-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0008403Molecular function25-hydroxycholecalciferol-24-hydroxylase activity
GO_0062180Molecular function25-hydroxycholecalciferol-23-hydroxylase activity

IV. Literature review

[source]
Gene nameCYP24A1
Protein name1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)
SynonymsCYP24
DescriptionFUNCTION: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) . With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid . With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product . Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin . .

AccessionsQ07973
ENST00000395954.3 [Q07973-3]
ENST00000395955.7 [Q07973-2]
ENST00000216862.8 [Q07973-1]